The HSP70 level significantly increased in OSA patients compared with the control group. Sleep fragmentation in OSA patients confirmed an increase in respiratory arousal index (ArI). Results - The results of this study demonstrated a high apnea/hypopnea index (AHI), which determined the OSA severity and decreased the blood oxygen saturation (SaO2) (p<0.05). Blood sampling for determining the HSP70 level was carried out between 8:00 and 9:00 am after polysomnographic monitoring. The polysomnographic monitoring was carried by standart methodology.
Patients without OSA (10 men and 5 women) were included as a control group. Material and Methods - The study involved 34 patients with a clinical diagnosis of moderate to severe OSA (24 men and 10 women). Thus, the objective of this study was to determine the relationship among nocturnal hypoxia and the serum HSP70 level in patients with severe OSA. Introduction - Nocturnal intermittent hypoxia in obstructive sleep apnea (OSA) causes cellular stress and consequent change in inducible heat shock protein 70 (HSP70) level.
